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Efficiency of whole genome amplification of single circulating tumor cells enriched by CellSearch and sorted by FACS

29 Nov 2013

Abstract excerpt

BACKGROUND: Tumor cells in the blood of patients with metastatic carcinomas are associated with poor survival. Knowledge of the cells' genetic make-up can help to guide targeted therapy. We evaluated the efficiency and quality of isolation and amplification of DNA from single circulating tumor cells (CTC). METHODS: The efficiency of the procedure was determined by spiking blood with SKBR-3 cells, enrichment with...

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PMID: 24286536
DOI: 10.1186/gm510

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