Article
Pancreatic circulating tumor cell detection by targeted single-cell next-generation sequencing.
Cancer letters - 28 Nov 2020
Yu Jun, Gemenetzis Georgios, Kinny-Köster Benedict, Habib Joseph R, Groot Vincent P, Teinor Jonathan, Yin Lingdi, Pu Ning, Hasanain Alina, van Oosten Floortje, Javed Ammar A, Weiss Matthew J, Burkhart Richard A, Burns William R, Goggins Michael, He Jin, Wolfgang Christopher L
Abstract excerpt
BACKGROUND AND AIMS: Single-cell next-generation sequencing (scNGS) technology has been widely used in genomic profiling, which relies on whole-genome amplification (WGA). However, WGA introduces errors and is especially less accurate when applied to single nucleotide variant (SNV) analysis. Targeted scNGS for SNV without WGA has not been described. We aimed to develop a method to detect circulating tumor cells...
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