Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Origins of Alzheimerʼs disease

5 Oct 2012

Abstract excerpt

PURPOSE OF REVIEW: This review aims to address the temporal sequencing of involvement of amyloid-beta (Aβ) and tau in the pathogenesis of Alzheimer's disease and reconcile apparently conflicting neuropathologic and biomarker data. RECENT FINDINGS: Although neuropathologic studies show that limbic system tau disease occurs ubiquitously in middle-aged individuals before the appearance of amyloid plaques, biomarker...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Dementia and Cognitive Impairment Research
Share to Neurological Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23041958
DOI: 10.1097/wco.0b013e32835a30f4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Origins of Alzheimerʼs diseasePMID 23041958Read ↗

Alzheimer’s Disease: Molecular Mechanisms of the Disease and Involved Factors — A Comprehensive Narrative ReviewSemantic proximity Read ↗

Mechanisms of neurodegeneration — Insights from familial Alzheimer’s diseaseSemantic proximity Read ↗

The Amyloid-β Pathway in Alzheimer’s DiseaseSemantic proximity Read ↗

Clinical and biomarker changes in dominantly inherited Alzheimer's disease.Semantic proximity Read ↗

Current Concepts of Neurodegenerative Mechanisms in Alzheimer's Disease.Semantic proximity Read ↗

On the origin of Alzheimer's disease. Trials and tribulations of the amyloid hypothesis.Semantic proximity Read ↗

Review article What causes alzheimer’s disease?Semantic proximity Read ↗

Epidemiology of Alzheimer disease.Semantic proximity Read ↗

Modes of Aβ toxicity in Alzheimer’s diseaseSemantic proximity Read ↗

The biological pathways of Alzheimer disease: a reviewSemantic proximity Read ↗

Alzheimer disease is multifactorial and heterogeneous.Semantic proximity Read ↗

Neurodegenerative mechanisms in alzheimer diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.