Article
Identification of the genomic mutation in Epha4(rb-2J/rb-2J) mice.
Genome - 1 Jul 2016
Mohd-Zin Siti W, Abdullah Nor-Linda, Abdullah Aminah, Greene Nicholas D E, Cheah Pike-See, Ling King-Hwa, Yusof Hadri, Marwan Ahmed I, Williams Sarah M, York Kerri T, Ahmad-Annuar Azlina, Abdul-Aziz Noraishah M
Abstract excerpt
The EphA4 receptor tyrosine kinase is involved in numerous cell-signalling activities during embryonic development. EphA4 has the ability to bind to both types of ephrin ligands, the ephrinAs and ephrinBs. The C57BL/6J-Epha4rb-2J/GrsrJ strain, denoted Epha4(rb-2J/rb-2J), is a spontaneous mouse mutant that arose at The Jackson Laboratory. These mutants exhibited a synchronous hind limb locomotion defect or...
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