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Article

A novel mouse Fgfr2 mutant, hobbyhorse (hob), exhibits complete XY gonadal sex reversal.

PloS one - 1 Jan 2014

Siggers Pam, Carré Gwenn-Aël, Bogani Debora, Warr Nick, Wells Sara, Hilton Helen, Esapa Chris, Hajihosseini Mohammad K, Greenfield Andy

Abstract excerpt

The secreted molecule fibroblast growth factor 9 (FGF9) plays a critical role in testis determination in the mouse. In embryonic gonadal somatic cells it is required for maintenance of SOX9 expression, a key determinant of Sertoli cell fate. Conditional gene targeting studies have identified FGFR2 as the main gonadal receptor for FGF9 during sex determination. However, such studies can be complicated by...

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Source

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Identifiers

PMID: 24956260
DOI: 10.1371/journal.pone.0100447
PMCID: PMC4067367

Genes

FGF9
FGFR2
SOX9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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