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A Continuous Statistical Phasing Framework for the Analysis of Forensic Mitochondrial DNA Mixtures.

Genes - 20 Jan 2021

Smart Utpal, Cihlar Jennifer Churchill, Mandape Sammed N, Muenzler Melissa, King Jonathan L, Budowle Bruce, Woerner August E

Abstract excerpt

Despite the benefits of quantitative data generated by massively parallel sequencing, resolving mitotypes from mixtures occurring in certain ratios remains challenging. In this study, a bioinformatic mixture deconvolution method centered on population-based phasing was developed and validated. The method was first tested on 270 in silico two-person mixtures varying in mixture proportions. An assortment of...

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Algorithms
Bayes Theorem
Computational Biology
DNA, Mitochondrial
Forensic Genetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome, Mitochondrial

Models, Statistical

Reproducibility of Results

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Identifiers

PMID: 33498312
DOI: 10.3390/genes12020128
PMCID: PMC7909279

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