Article
Exposing malaria in-host diversity and estimating population diversity by capture-recapture using massively parallel pyrosequencing.
Proceedings of the National Academy of Sciences of the United States of America - 16 Nov 2010
Juliano Jonathan J, Porter Kimberly, Mwapasa Victor, Sem Rithy, Rogers William O, Ariey Frédéric, Wongsrichanalai Chansuda, Read Andrew, Meshnick Steven R
Abstract excerpt
Malaria infections commonly contain multiple genetically distinct variants. Mathematical and animal models suggest that interactions among these variants have a profound impact on the emergence of drug resistance. However, methods currently used for quantifying parasite diversity in individual in...
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