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Article

Single-cell genomics for dissection of complex malaria infections.

Genome research - 1 Jun 2014

Nair Shalini, Nkhoma Standwell C, Serre David, Zimmerman Peter A, Gorena Karla, Daniel Benjamin J, Nosten François, Anderson Timothy J C, Cheeseman Ian H

Abstract excerpt

Most malaria infections contain complex mixtures of distinct parasite lineages. These multiple-genotype infections (MGIs) impact virulence evolution, drug resistance, intra-host dynamics, and recombination, but are poorly understood. To address this we have developed a single-cell genomics approach to dissect MGIs. By combining cell sorting and whole-genome amplification (WGA), we are able to generate...

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Identifiers

PMID: 24812326
DOI: 10.1101/gr.168286.113
PMCID: PMC4032849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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