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Article

Inducible nephrin transgene expression in podocytes rescues nephrin-deficient mice from perinatal death.

The American journal of pathology - 1 Jan 2010

Juhila Juuso, Lassila Markus, Roozendaal Ramon, Lehtonen Eero, Messing Marcel, Langer Brigitte, Kerjaschki Dontscho, Verbeek J Sjef, Holthofer Harry

Abstract excerpt

Mutations leading to nephrin loss result in massive proteinuria both in humans and mice. Early perinatal lethality of conventional nephrin knockout mice makes it impossible to determine the role of nephrin protein in the adult kidney and in extra-renal tissues. Herein, we studied whether podocyte-specific, doxycycline-inducible, rat nephrin expression can rescue nephrin-deficient mice from perinatal lethality....

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Identifiers

PMID: 19948823
DOI: 10.2353/ajpath.2010.080843
PMCID: PMC2797869

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