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Article

Identification of a Disulfide Bridge in Sodium-Coupled Neutral Amino Acid Transporter 2(SNAT2) by Chemical Modification.

PloS one - 1 Jan 2016

Chen Chen, Wang Jiahong, Cai Ruiping, Yuan Yanmeng, Guo Zhanyun, Grewer Christof, Zhang Zhou

Abstract excerpt

Sodium-coupled neutral amino acid transporter 2 (SNAT2) belongs to solute carrier 38 (SLC38) family of transporters, which is ubiquitously expressed in mammalian tissues and mediates transport of small, neutral amino acids, exemplified by alanine(Ala, A). Yet structural data on SNAT2, including the relevance of intrinsic cysteine residues on structure and function, is scarce, in spite of its essential roles in...

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PMID: 27355203
DOI: 10.1371/journal.pone.0158319
PMCID: PMC4927162

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