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Article

Claudin-2 pore function requires an intramolecular disulfide bond between two conserved extracellular cysteines.

American journal of physiology. Cell physiology - 15 Jul 2013

Li Jiahua, Angelow Susanne, Linge Anna, Zhuo Min, Yu Alan S L

Abstract excerpt

Claudins constitute a family of tight junction transmembrane proteins whose first extracellular loop (ECL1) determines the paracellular permeability and ion selectivity in epithelia. There are two cysteines in the ECL1 that are conserved among all claudins. We hypothesized that these extracellula...

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Identifiers

PMID: 23677799
DOI: 10.1152/ajpcell.00074.2013
PMCID: PMC3725624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23677799-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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