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Article

Direct evidence that two cysteines in the dopamine transporter form a disulfide bond.

Molecular and cellular biochemistry - 1 Apr 2007

Chen Rong, Wei Hua, Hill Erik R, Chen Lucy, Jiang Liying, Han Dawn D, Gu Howard H

Abstract excerpt

We have generated a fully functional dopamine transporter (DAT) mutant (dmDATx7) with all cysteines removed except the two cysteines in extracellular loop 2 (EL2). Random mutagenesis at either or both EL2 cysteines did not produce any functional transporter mutants, suggesting that the two cysteines cannot be replaced by any other amino acids. The cysteine-specific reagent MTSEA-biotin labeled dmDATx7 only after...

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Source

Identifiers

PMID: 17131045
DOI: 10.1007/s11010-006-9348-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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