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Article

Highly conserved asparagine 82 controls the interaction of Na+ with the sodium-coupled neutral amino acid transporter SNAT2.

The Journal of biological chemistry - 2 May 2008

Zhang Zhou, Gameiro Armanda, Grewer Christof

Abstract excerpt

The neutral amino acid transporter 2 (SNAT2), which belongs to the SLC38 family of solute transporters, couples the transport of amino acid to the cotransport of one Na(+) ion into the cell. Several polar amino acids are highly conserved within the SLC38 family. Here, we mutated three of these conserved amino acids, Asn(82) in the predicted transmembrane domain 1 (TMD1), Tyr(337) in TMD7, and Arg(374) in TMD8;...

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Identifiers

PMID: 18319257
DOI: 10.1074/jbc.M706774200
PMCID: PMC2430088

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Source receipt: pubmed, retrieved 7 Sept 2026.

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