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Article

Structural insights into thyroid hormone transport mechanisms of the L-type amino acid transporter 2.

Molecular endocrinology (Baltimore, Md.) - 1 Jun 2015

Hinz Katrin M, Meyer Katja, Kinne Anita, Schülein Ralf, Köhrle Josef, Krause Gerd

Abstract excerpt

Thyroid hormones (THs) are transported across cell membranes by different transmembrane transporter proteins. In previous studies, we showed marked 3,3'-diiodothyronine (3,3'-T2) but moderate T3 uptake by the L-type amino acid transporter 2 (Lat2). We have now studied the structure-function relationships of this transporter and TH-like molecules. Our Lat2 homology model is based on 2 crystal structures of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25945809
DOI: 10.1210/me.2015-1044
PMCID: PMC5414734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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