Article
ContEst: estimating cross-contamination of human samples in next-generation sequencing data.
Bioinformatics (Oxford, England) - 15 Sept 2011
Cibulskis Kristian, McKenna Aaron, Fennell Tim, Banks Eric, DePristo Mark, Getz Gad
Abstract excerpt
SUMMARY: Here, we present ContEst, a tool for estimating the level of cross-individual contamination in next-generation sequencing data. We demonstrate the accuracy of ContEst across a range of contamination levels, sources and read depths using sequencing data mixed in silico at known concentrations. We applied our tool to published cancer sequencing datasets and report their estimated contamination levels....
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