Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dedicator of cytokinesis 8 (DOCK8) deficiency.

Current opinion in allergy and clinical immunology - 1 Dec 2010

Su Helen C

Abstract excerpt

PURPOSE OF REVIEW: To describe a new combined primary immunodeficiency disease, previously known as autosomal recessive hyper-IgE syndrome, whose molecular basis was discovered in 2009. RECENT FINDINGS: Two groups identified homozygous and compound heterozygous loss-of-function mutations in the Dedicator of cytokinesis 8 (DOCK8) gene in at least 30 patients who had been previously diagnosed with an atypical form...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immunity, Humoral
Share to Infections
Share to Job Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphopenia

Share to T-Lymphocytes

Share to Cell Proliferation

Share to Disease Models, Animal

Share to Guanine Nucleotide Exchange Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 20864884
DOI: 10.1097/ACI.0b013e32833fd718
PMCID: PMC3096565

Genes

DOCK8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dedicator of cytokinesis 8 (DOCK8) deficiency.PMID 20864884Read ↗

The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency.Semantic proximity Read ↗

Cutaneous manifestations of DOCK8 deficiency syndrome.Semantic proximity Read ↗

The clinical and laboratory spectrum of dedicator of cytokinesis 8 immunodeficiency syndrome in patients with a unique mutation.Semantic proximity Read ↗

Recent Advances in DOCK8 Immunodeficiency Syndrome.Semantic proximity Read ↗

Insights into immunity from clinical and basic science studies of DOCK 8 immunodeficiency syndromeSemantic proximity Read ↗

Genetic, clinical, and laboratory markers for DOCK8 immunodeficiency syndrome.Semantic proximity Read ↗

Exome-first Approach Identified Novel Homozygous Dedicator of Cytokinesis 8 (DOCK8) Mutations in Three Unrelated Iranian Pedigrees Suspected with Hyper-IgE Syndrome.Semantic proximity Read ↗

DOCK8 Deficiency Presenting as an IPEX-Like Disorder.Semantic proximity Read ↗

Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome.Semantic proximity Read ↗

The essential role of DOCK8 in humoral immunity.Semantic proximity Read ↗

Dedicator of cytokinesis 8 regulates signal transducer and activator of transcription 3 activation and promotes TH17 cell differentiation.Semantic proximity Read ↗

DOCK8-related Immunodeficiency Syndrome (DIDS): Report of Novel Mutations in Iranian Patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.