Article
Biological and clinical significance of T helper 17 cell deficiency: insight into monogenic defects.
European annals of allergy and clinical immunology - 1 Jul 2021
Anka A U, Abdullahi I N, Umar K, Bello Z M, Mohammed M, Gachpaz Sarkhiz S, Abubakar N K, Alsabbagh M, Kamali A N, Azizi G
Abstract excerpt
Summary: T helper 17 (Th17) are a CD4+ T subpopulation cells which are involved in the host protection against microbes such as extracellular and intracellular bacteria, parasites, fungi, and viruses. Monogenic defects including those mutations in some genes such as the signal transducer and activator of transcription (STAT)1 and 3, dedicator of cytokinesis 8 (DOCK8), autoimmune regulator (AIRE), and interleukin...
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