Article
Diagnostic challenge in a series of eleven patients with hyper IgE syndromes.
Frontiers in immunology - 1 Jan 2022
Yaakoubi Roukaya, Mekki Najla, Ben-Mustapha Imen, Ben-Khemis Leila, Bouaziz Asma, Ben Fraj Ilhem, Ammar Jamel, Hamzaoui Agnès, Turki Hamida, Boussofara Lobna, Denguezli Mohamed, Haddad Samir, Ouederni Monia, Bejaoui Mohamed, Chan Koon Wing, Lau Yu Lung, Mellouli Fethi, Barbouche Mohamed-Ridha, Ben-Ali Meriem
Abstract excerpt
Hyper IgE syndromes (HIES) is a heterogeneous group of Inborn Errors of Immunity characterized by eczema, recurrent skin and lung infections associated with eosinophilia and elevated IgE levels. Autosomal dominant HIES caused by loss of function mutations in Signal transducer and activator of transcription 3 (STAT3) gene is the prototype of these disorders. Over the past two decades, advent in genetic testing...
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