Article

Loss of TIM4-Dependent Efferocytosis in Kupffer Cells Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

2024-02-02

Abstract excerpt

<h4>Background and aims</h4> Hepatocyte apoptosis is a key feature of non-alcoholic steatohepatitis (NASH), but the fate of apoptotic hepatocytes in NASH is poorly understood. Herein we explore the hypothesis that impaired TIM4-mediated clearance of dead hepatocytes by liver macrophages (efferocytosis) is impaired in NASH and drives the progression to liver fibrosis. <h4>Methods</h4> Kupffer cell (KC)-TIM4 expre...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2b91952f-0e8f-58ea-8ee4-212b1053df27
DOI: 10.1101/2024.01.30.578023

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of TIM4-Dependent Efferocytosis in Kupffer Cells Promotes Liver Fibrosis in Nonalcoholic SteatohepatitisDOI 10.1101/2024.01.30.578023Read

Targeting cell death in NAFLD: mechanisms and targeted therapiesSemantic proximity Read

Kupffer Cells Undergo Fundamental Changes during the Development of Experimental NASH and Are Critical in Initiating Liver Damage and InflammationSemantic proximity Read

CD11c+ resident macrophages drive hepatocyte death-triggered liver fibrosis in a murine model of nonalcoholic steatohepatitisSemantic proximity Read

Ambiguous Pathogenic Roles of Macrophages in Alcohol-Associated Liver DiseasesSemantic proximity Read

Macrophage Phenotype and Function in Liver Disorder.Semantic proximity Read

The transcription factor ATF3 switches cell death from apoptosis to necroptosis in hepatic steatosis in male miceSemantic proximity Read

Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis.Semantic proximity Read

Investigating the role of ferroptosis in the pathogenesis of murine models of metabolic dysfunction-associated steatohepatitis (MASH)Semantic proximity Read

Hepatocyte-specific NR5A2 deficiency induces pyroptosis and exacerbates non-alcoholic steatohepatitis by downregulating ALDH1B1 expressionSemantic proximity Read

Apoptosis and Necrosis in the LiverSemantic proximity Read

Apoptosis: The nexus of liver injury and fibrosisSemantic proximity Read

MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming.Semantic proximity Read