Article
The central cannabinoid CB1 receptor is required for diet-induced obesity and rimonabant's antiobesity effects in mice.
Obesity (Silver Spring, Md.) - 1 Oct 2011
Pang Zhen, Wu Nancy N, Zhao Weiguang, Chain David C, Schaffer Erica, Zhang Xin, Yamdagni Preeti, Palejwala Vaseem A, Fan Chunpeng, Favara Sarah G, Dressler Holly M, Economides Kyriakos D, Weinstock Daniel, Cavallo Jean S, Naimi Souad, Galzin Anne-Marie, Guillot Etienne, Pruniaux Marie-Pierre, Tocci Michael J, Polites H Greg
Abstract excerpt
Cannabinoid receptor CB1 is expressed abundantly in the brain and presumably in the peripheral tissues responsible for energy metabolism. It is unclear if the antiobesity effects of rimonabant, a CB1 antagonist, are mediated through the central or the peripheral CB1 receptors. To address this question, we generated transgenic mice with central nervous system (CNS)-specific knockdown (KD) of CB1, by expressing an...
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