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Article

Uncoupling of the base excision and nucleotide incision repair pathways reveals their respective biological roles.

Proceedings of the National Academy of Sciences of the United States of America - 21 Feb 2006

Ishchenko Alexander A, Deprez Eric, Maksimenko Andrei, Brochon Jean-Claude, Tauc Patrick, Saparbaev Murat K

Abstract excerpt

The multifunctional DNA repair enzymes apurinic/apyrimidinic (AP) endonucleases cleave DNA at AP sites and 3'-blocking moieties generated by DNA glycosylases in the base excision repair pathway. Alternatively, in the nucleotide incision repair (NIR) pathway, the same AP endonucleases incise DNA 5' of a number of oxidatively damaged bases. At present, the physiological relevance of latter function remains unclear....

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Identifiers

PMID: 16473948
DOI: 10.1073/pnas.0508582103
PMCID: PMC1413785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Uncoupling of the base excision and nucleotide incision repair pathways reveals their respective biological roles.PMID 16473948Read ↗

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