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Article

Intranasal Administration of a Polyethylenimine-Conjugated Scavenger Peptide Reduces Amyloid-β Accumulation in a Mouse Model of Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 18 Jun 2016

Lin Chih-Yun, Cheng Yu-Sung, Liao Tai-Yan, Lin Chen, Chen Zih-Ten, Twu Woan-Ing, Chang Chi-Wei, Tan David Tat-Wei, Liu Ren-Shyan, Tu Pang-Hsien, Chen Rita P-Y

Abstract excerpt

Amyloid-β (Aβ) aggregation in the brain plays a central and initiatory role in pathogenesis and/or progression of Alzheimer's disease (AD). Inhibiting Aβ aggregation is a potential strategy in the prevention of AD. A scavenger peptide, V24P(10-40), designed to decrease Aβ accumulation in the brain, was conjugated to polyethylenimine (PEI) and tested as a preventive/therapeutic strategy for AD in this study. This...

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Identifiers

PMID: 27340844
DOI: 10.3233/JAD-151024

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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