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Article

Structural basis for membrane anchoring of HIV-1 envelope spike.

Science (New York, N.Y.) - 8 Jul 2016

Dev Jyoti, Park Donghyun, Fu Qingshan, Chen Jia, Ha Heather Jiwon, Ghantous Fadi, Herrmann Tobias, Chang Weiting, Liu Zhijun, Frey Gary, Seaman Michael S, Chen Bing, Chou James J

Abstract excerpt

HIV-1 envelope spike (Env) is a type I membrane protein that mediates viral entry. We used nuclear magnetic resonance to determine an atomic structure of the transmembrane (TM) domain of HIV-1 Env reconstituted in bicelles that mimic a lipid bilayer. The TM forms a well-ordered trimer that protects a conserved membrane-embedded arginine. An amino-terminal coiled-coil and a carboxyl-terminal hydrophilic core...

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Share to HIV Antibodies
Share to HIV Envelope Protein gp41

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipid Bilayers

Share to Membrane Fusion

Share to Nuclear Magnetic Resonance, Biomolecular

Share to Protein Multimerization

Share to Protein Stability

Share to Virus Internalization

Source

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Identifiers

PMID: 27338706
DOI: 10.1126/science.aaf7066
PMCID: PMC5085267

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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