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Article

Per-Arnt-Sim kinase regulates pancreatic duodenal homeobox-1 protein stability via phosphorylation of glycogen synthase kinase 3β in pancreatic β-cells.

The Journal of biological chemistry - 23 Aug 2013

Semache Meriem, Zarrouki Bader, Fontés Ghislaine, Fogarty Sarah, Kikani Chintan, Chawki Mohammad B, Rutter Jared, Poitout Vincent

Abstract excerpt

In pancreatic β-cells, glucose induces the binding of the transcription factor pancreatic duodenal homeobox-1 (PDX-1) to the insulin gene promoter to activate insulin gene transcription. At low glucose levels, glycogen synthase kinase 3β (GSK3β) is known to phosphorylate PDX-1 on C-terminal serin...

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Identifiers

PMID: 23853095
DOI: 10.1074/jbc.M113.495945
PMCID: PMC3750177

Genes

PASK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23853095-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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