Article
Rheumatoid Arthritis: The Stride from Research to Clinical Practice.
International journal of molecular sciences - 8 Jun 2016
Chung Ill-Min, Ketharnathan Sarada, Thiruvengadam Muthu, Rajakumar Govindasamy
Abstract excerpt
Over 70 different genetic variants with a significant association with rheumatoid arthritis (RA) have been discovered. Anti-citrullination protein antibodies (ACPA)-positive RA variants are more well-defined than their ACPA-negative counterparts. The human leukocyte antigen, HLA-DRB1 locus remains the prime suspect in anti-citrullination protein antibodies (ACPA)-positive RA. Different HLA-DRB1 alleles are linked...
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