Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of a 3rd Na+ Binding Site of the Glycine Transporter, GlyT2.

PloS one - 1 Jan 2016

Subramanian Nandhitha, Scopelitti Amanda J, Carland Jane E, Ryan Renae M, O'Mara Megan L, Vandenberg Robert J

Abstract excerpt

The Na+/Cl- dependent glycine transporters GlyT1 and GlyT2 regulate synaptic glycine concentrations. Glycine transport by GlyT2 is coupled to the co-transport of three Na+ ions, whereas transport by GlyT1 is coupled to the co-transport of only two Na+ ions. These differences in ion-flux coupling determine their respective concentrating capacities and have a direct bearing on their functional roles in synaptic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Models, Molecular
Share to Molecular Dynamics Simulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Recombinant Proteins

Share to Sequence Homology, Amino Acid

Share to Sodium

Share to Xenopus laevis

Source

Open in PubMed Open full text

Identifiers

PMID: 27337045
DOI: 10.1371/journal.pone.0157583
PMCID: PMC4919009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a 3rd Na+ Binding Site of the Glycine Transporter, GlyT2.PMID 27337045Read ↗

Molecular basis for substrate discrimination by glycine transporters.Semantic proximity Read ↗

Discovery of New Classes of Glycine transporter 2 (GlyT2) Inhibitors and Study of GlyT2 Selectivity by Combination of Novel Structural Based Virtual Screening Approach and Free Energy Perturbation (FEP+) CalculationsSemantic proximity Read ↗

Chloride-dependent conformational changes in the GlyT1 glycine transporterSemantic proximity Read ↗

Role of palmitoylation on the neuronal glycine transporter GlyT2.Semantic proximity Read ↗

A critical role for glycine transporters in hyperexcitability disordersSemantic proximity Read ↗

Molecular basis of the dominant negative effect of a glycine transporter 2 mutation associated with hyperekplexia.Semantic proximity Read ↗

Ubiquitin ligase LNX1 is a major regulator of glycine recapture by the presynaptic transporter GlyT2Semantic proximity Read ↗

Computational modelling of the glycinergic synapseSemantic proximity Read ↗

Interaction of GAT1 with sodium ions: from efficient recruitment to stabilisation of substrate and conformationSemantic proximity Read ↗

Mechanisms of endoplasmic-reticulum export of glycine transporter-1 (GLYT1).Semantic proximity Read ↗

Mechanism of chloride interaction with neurotransmitter:sodium symporters.Semantic proximity Read ↗

Hyperekplexia-associated mutations in the neuronal glycine transporter 2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.