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Article

cGAS-STING Signaling Regulates Initial Innate Control of Cytomegalovirus Infection

24 Jun 2016

Abstract excerpt

ABSTRACT Several innate sensing pathways contribute to the control of early cytomegalovirus (CMV) infection, leading to a multiphasic type I interferon (IFN-I) response that limits viral replication and promotes host defenses. Toll-like receptor (TLR)-dependent pathways induce IFN-I production in CMV-infected plasmacytoid dendritic cells; however, the initial burst of IFN-I that occurs within the first few hours...

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PMID: 27334590
DOI: 10.1128/jvi.01040-16

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