Article
Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular Mechanism.
PloS one - 1 Jan 2016
Chua Han Chow, Christensen Emilie T H, Hoestgaard-Jensen Kirsten, Hartiadi Leonny Y, Ramzan Iqbal, Jensen Anders A, Absalom Nathan L, Chebib Mary
Abstract excerpt
Extracts of the pepper plant kava (Piper methysticum) are effective in alleviating anxiety in clinical trials. Despite the long-standing therapeutic interest in kava, the molecular target(s) of the pharmacologically active constituents, kavalactones have not been established. γ-Aminobutyric acid type A receptors (GABAARs) are assumed to be the in vivo molecular target of kavalactones based on data from binding...
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