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Article

Valerenic acid potentiates and inhibits GABA(A) receptors: molecular mechanism and subunit specificity.

Neuropharmacology - 1 Jul 2007

Khom S, Baburin I, Timin E, Hohaus A, Trauner G, Kopp B, Hering S

Abstract excerpt

Valerian is a commonly used herbal medicinal product for the treatment of anxiety and insomnia. Here we report the stimulation of chloride currents through GABA(A) receptors (I(GABA)) by valerenic acid (VA), a constituent of Valerian. To analyse the molecular basis of VA action, we expressed GABA(A) receptors with 13 different subunit compositions in Xenopus oocytes and measured I(GABA) using the...

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Identifiers

PMID: 17585957
DOI: 10.1016/j.neuropharm.2007.04.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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