Article
An allosteric antibody to the leptin receptor reduces body weight and reverses the diabetic phenotype in the Lep(ob) /Lep(ob) mouse.
Obesity (Silver Spring, Md.) - 1 Aug 2016
Bhaskar Vinay, Goldfine Ira D, Gerstner Resi, Michelson Kristen, Tran Catarina, Nonet Genevieve, Bohmann David, Pongo Elizabeth, Zhao Jingsong, Horwitz Arnold H, Takeuchi Toshihiko, White Mark, Corbin John A
Abstract excerpt
OBJECTIVE: Leptin (LEP) deficiency results in major metabolic perturbations, including obesity, dyslipidemia, and diabetes. Although LEP deficiency can be treated with daily injections of a recombinant LEP, generation of an antibody activating the LEP receptor (LEPR) that has both an intrinsically long half-life and low immunogenicity could be useful in the treatment of this condition. METHODS: Phage display...
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