Article
Crystal structure of the obese protein leptin-E100.
Nature - 8 May 1997
Zhang F, Basinski M B, Beals J M, Briggs S L, Churgay L M, Clawson D K, DiMarchi R D, Furman T C, Hale J E, Hsiung H M, Schoner B E, Smith D P, Zhang X Y, Wery J P, Schevitz R W
Abstract excerpt
Mutations in the obese gene (OB) or in the gene encoding the OB receptor(OB-R) result in obesity, infertility and diabetes in a variety of mouse phenotypes. The demonstration that OB protein (also known as leptin) can normalize body weight in ob/ob mice has generated enormous interest. Most human obesity does not appear to result from a mutant form of leptin: rather, serum leptin concentrations are increased and...
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