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Article

Identification of amino acid residues in the insect sodium channel critical for pyrethroid binding.

Molecular pharmacology - 1 Feb 2005

Tan Jianguo, Liu Zhiqi, Wang Ruiwu, Huang Zachary Y, Chen Andrew C, Gurevitz Michael, Dong Ke

Abstract excerpt

The voltage-gated sodium channel is the primary target site of pyrethroids, which constitute a major class of insecticides used worldwide. Pyrethroids prolong the opening of sodium channels by inhibiting deactivation and inactivation. Despite numerous attempts to characterize pyrethroid binding to sodium channels in the past several decades, the molecular determinants of the pyrethroid binding site on the sodium...

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PMID: 15525757
DOI: 10.1124/mol.104.006205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Identification of amino acid residues in the insect sodium channel critical for pyrethroid binding.PMID 15525757Read ↗

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