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Article

The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongation.

Nature immunology - 1 Aug 2016

Shang Yingli, Coppo Maddalena, He Teng, Ning Fei, Yu Li, Kang Lan, Zhang Bin, Ju Chanyang, Qiao Yu, Zhao Baohong, Gessler Manfred, Rogatsky Inez, Hu Xiaoyu

Abstract excerpt

Most of the known regulatory mechanisms that curb inflammatory gene expression target pre-transcription-initiation steps, and evidence for post-initiation regulation of inflammatory gene expression remains scarce. We found that the transcriptional repressor Hes1 suppressed production of CXCL1, a chemokine that is crucial for recruiting neutrophils. Hes1 negatively regulated neutrophil recruitment in vivo in a...

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Source

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Identifiers

PMID: 27322654
DOI: 10.1038/ni.3486
PMCID: PMC4955730

Genes

CXCL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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