Inhibition of Endothelial NOTCH1 Signaling Attenuates Inflammation by Reducing Cytokine-Mediated Histone Acetylation at Inflammatory Enhancers.

doi:10.1161/ATVBAHA.117.310388

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Article

Inhibition of Endothelial NOTCH1 Signaling Attenuates Inflammation by Reducing Cytokine-Mediated Histone Acetylation at Inflammatory Enhancers.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2018

Poulsen Lars la Cour, Edelmann Reidunn Jetne, Krüger Stig, Diéguez-Hurtado Rodrigo, Shah Akshay, Stav-Noraas Tor Espen, Renzi Anastasia, Szymanska Monika, Wang Junbai, Ehling Manuel, Benedito Rui, Kasprzycka Monika, Bækkevold Espen, Sundnes Olav, Midwood Kim S, Scott Helge, Collas Philippe, Siebel Christian W, Adams Ralf H, Haraldsen Guttorm, Sundlisæter Eirik, Hol Johanna

Abstract excerpt

OBJECTIVE: Endothelial upregulation of adhesion molecules serves to recruit leukocytes to inflammatory sites and appears to be promoted by NOTCH1; however, current models based on interactions between active NOTCH1 and NF-κB components cannot explain the transcriptional selectivity exerted by NOTCH1 in this context. APPROACH AND RESULTS: Observing that Cre/Lox-induced conditional mutations of endothelial Notch...

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Identifiers

PMID: 29449332
DOI: 10.1161/ATVBAHA.117.310388

Genes

NOTCH1
RBPJ
RELA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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