Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inflammation-inducible promoters to overexpress immune inhibitory factors by MSCs

23 Sept 2023

Abstract excerpt

BACKGROUND: Mesenchymal stromal cells (MSCs) are excessively investigated in the context of inflammation-driven diseases, but the clinical results are often moderate. MSCs are naturally activated by inflammatory signals, which lead to the secretion of immune inhibitory factors in inflamed tissues. Many work groups try to improve the therapeutic outcome of MSCs by genetic modification and the constitutive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemokine receptors and signaling
Share to Mesenchymal stem cell research
Share to RNA Interference and Gene Delivery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37742038
DOI: 10.1186/s13287-023-03501-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inflammation-inducible promoters to overexpress immune inhibitory factors by MSCsPMID 37742038Read ↗

Inflammatory Cytokines in Cancer: Comprehensive Understanding and Clinical Progress in Gene TherapySemantic proximity Read ↗

Enhanced anti-inflammatory effects of mesenchymal stromal cells mediated by the transient ectopic expression of CXCR4 and IL10Semantic proximity Read ↗

Characterization of Constitutive Promoters for piggyBac Transposon-Mediated Stable Transgene Expression in Mesenchymal Stem Cells (MSCs)Semantic proximity Read ↗

Synthetic promoters to induce immune-effectors into the tumor microenvironmentSemantic proximity Read ↗

IL-17 Triggers Invasive and Migratory Properties in Human MSCs, while IFNy Favors their Immunosuppressive Capabilities: Implications for the "Licensing" Process.Semantic proximity Read ↗

CRISPR-Based Epigenome Editing of Cytokine Receptors for the Promotion of Cell Survival and Tissue Deposition in Inflammatory EnvironmentsSemantic proximity Read ↗

A Clinical Indications Prediction Scale Based on TWIST1 for Human Mesenchymal Stem CellsSemantic proximity Read ↗

Architecture Matters: Design Rules for Multigene IDO1/PD-L1 Cassettes in Human Skin CellsSemantic proximity Read ↗

CUX1 and IκBζ mediate the synergistic inflammatory response to TNF and IL-17A in stromal fibroblastsSemantic proximity Read ↗

Engineering of the CMV promoter for controlled expression of recombinant genes in HEK293 cellsSemantic proximity Read ↗

CUX1 and IκBζ (NFKBIZ) mediate the synergistic inflammatory response to TNF and IL-17A in stromal fibroblastsSemantic proximity Read ↗

Quantitative Analyses of Core Promoters Enable Precise Engineering of Regulated Gene Expression in Mammalian CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.