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Article

MMP-13 is one of the critical mediators of the effect of HDAC4 deletion on the skeleton.

Bone - 1 Sept 2016

Nakatani Teruyo, Chen Tiffany, Partridge Nicola C

Abstract excerpt

Histone deacetylase 4 (Hdac4) regulates chondrocyte hypertrophy. Hdac4(-/-) mice are runted in size and do not survive to weaning. This phenotype is primarily due to the acceleration of onset of chondrocyte hypertrophy and, as a consequence, inappropriate endochondral mineralization. Previously, we reported that Hdac4 is a repressor of matrix metalloproteinase-13 (Mmp13) transcription, and the absence of Hdac4...

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Source

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Identifiers

PMID: 27320207
DOI: 10.1016/j.bone.2016.06.010
PMCID: PMC4970950

Genes

HDAC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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MMP-13 is one of the critical mediators of the effect of HDAC4 deletion on the skeleton.PMID 27320207Read ↗

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