Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification.

Proceedings of the National Academy of Sciences of the United States of America - 7 Dec 2004

Inada Masaki, Wang Yingmin, Byrne Michael H, Rahman Mahboob U, Miyaura Chisato, López-Otín Carlos, Krane Stephen M

Abstract excerpt

Collagenase-3 (MMP13), a member of the matrix metalloproteinase (MMP) family of neutral endopeptidases, is expressed in the skeleton during embryonic development and is highly overexpressed in human carcinomas and in chondrocytes and synovial cells in rheumatoid arthritis and osteoarthritis. To determine the functional roles of Mmp13, we generated Mmp13-null mice that showed profound defects in growth plate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cartilage
Share to Collagenases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exostoses, Multiple Hereditary

Share to Extremities

Share to Growth Plate

Share to Histocytochemistry

Share to Matrix Metalloproteinase 13

Share to Ossification, Heterotopic

Source

Open in PubMed Open full text

Identifiers

PMID: 15563592
DOI: 10.1073/pnas.0407788101
PMCID: PMC535367

Genes

MMP13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification.PMID 15563592Read ↗

Altered endochondral bone development in matrix metalloproteinase 13-deficient mice.Semantic proximity Read ↗

Matrix metalloproteinases: role in skeletal development and growth plate disordersSemantic proximity Read ↗

MMP-13 is one of the critical mediators of the effect of HDAC4 deletion on the skeleton.Semantic proximity Read ↗

Matrilin-3 Is Dispensable for Mouse Skeletal Growth and DevelopmentSemantic proximity Read ↗

Abnormal bone quality in cartilage oligomeric matrix protein and matrilin 3 double-deficient mice caused by increased tissue inhibitor of metalloproteinases 3 deposition and delayed aggrecan degradation.Semantic proximity Read ↗

Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritis.Semantic proximity Read ↗

Mutations in MMP9 and MMP13 determine the mode of inheritance and the clinical spectrum of metaphyseal anadysplasia.Semantic proximity Read ↗

Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritisSemantic proximity Read ↗

Decreased chondrocyte proliferation and dysregulated apoptosis in the cartilage growth plate are key features of a murine model of epiphyseal dysplasia caused by a matn3 mutation.Semantic proximity Read ↗

SERPINA3 is a marker of cartilage differentiation and is essential for the expression of extracellular matrix genes during early chondrogenesisSemantic proximity Read ↗

Matrix Metalloproteinase 3: A Promoting and Destabilizing Factor in the Pathogenesis of Disease and Cell DifferentiationSemantic proximity Read ↗

Matrix metalloproteinase 13 loss associated with impaired extracellular matrix remodeling disrupts chondrocyte differentiation by concerted effects on multiple regulatory factorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.