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Article

Fc Galactosylation Promotes Hexamerization of Human IgG1, Leading to Enhanced Classical Complement Activation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2021

van Osch Thijs L J, Nouta Jan, Derksen Ninotska I L, van Mierlo Gerard, van der Schoot C Ellen, Wuhrer Manfred, Rispens Theo, Vidarsson Gestur

Abstract excerpt

Human IgG contains one evolutionarily conserved N-linked glycan in its Fc region at position 297. This glycan is crucial for Fc-mediated functions, including its induction of the classical complement cascade. This is induced after target recognition through the IgG-Fab regions, allowing neighboring IgG-Fc tails to associate through Fc:Fc interaction, ultimately leading to hexamer formation. This hexamerization...

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Identifiers

PMID: 34408013
DOI: 10.4049/jimmunol.2100399
PMCID: PMC8428746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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