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Article

The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR.

Journal of experimental & clinical cancer research : CR - 18 Jun 2016

Zhao Shuai, Cao Yang, Liu Shi-Bo, Wang Xu-An, Bao Run-Fa, Shu Yi-Jun, Hu Yun-Ping, Zhang Yi-Jian, Jiang Lin, Zhang Fei, Liang Hai-Bin, Li Huai-Feng, Ma Qiang, Xu Yi, Wang Zheng, Zhang Yi-Chi, Chen Lei, Zhou Jian, Liu Ying-Bin

Abstract excerpt

BACKGROUND: Gallbladder carcinoma (GBC) is the most common malignancy of the bile duct and patients with GBC have extremely poor prognoses. PIK3CA, which encodes the phosphoinositide 3-kinase (PI3K) subunit p110α, is frequently mutated in many cancers, including GBC. The function of the E545K mutation in GBC is not fully understood. METHODS: E545K mutation was determined in human GBC tissues by targeted...

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Identifiers

PMID: 27317099
DOI: 10.1186/s13046-016-0370-7
PMCID: PMC4912708

Genes

EGFR
CCK

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