Article
Identification of MAP kinase pathways as therapeutic targets in gallbladder carcinoma using targeted parallel sequencing.
Oncotarget - 30 May 2017
Li Mengdan, Chen Lihong, Qu Yiping, Sui Fang, Yang Qi, Ji Meiju, Shi Bingyin, Chen Mingwei, Hou Peng
Abstract excerpt
The aim of this study was to profile somatic mutation spectrum in gallbladder cancers (GBCs), and determine the role of MAP kinase pathway in GBC by a series of in vitro and in vivo studies. We performed targeted massively parallel sequencing of DNA isolated from GBCs and matched blood from 14 GBC patients to search for mutations in 504 genes commonly altered in human cancers. We identified recurrent mutations...
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