Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic Mutations of PI3K in Early and Advanced Gallbladder Cancer: Additional Options for an Orphan Cancer.

The Journal of molecular diagnostics : JMD - 1 May 2016

Roa Ivan, Garcia Hernan, Game Anakaren, de Toro Gonzalo, de Aretxabala Xabier, Javle Milind

Abstract excerpt

Gallbladder cancer (GBC) is the second-leading cause of death from malignant tumors in Chilean women. The phosphatidylinositol 3-kinase (PI3K) pathway is involved in proliferation, cell survival, and growth. We investigated mutations in exons 9 and 20 of the PI3K gene in GBC. Mutations in exons 9 (E542K, E545G, E545K) and 20 (H1047L and H1047R) of PI3K were determined by direct sequencing in 130 cases of GBC. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gallbladder Neoplasms

Share to Neoplasm Staging

Share to Phosphatidylinositol 3-Kinases

Share to Prognosis

Share to Rare Diseases

Source

Identifiers

PMID: 26947513
DOI: 10.1016/j.jmoldx.2015.12.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic Mutations of PI3K in Early and Advanced Gallbladder Cancer: Additional Options for an Orphan Cancer.PMID 26947513Read ↗

Gallbladder cancer in Chile: what have we learned?Semantic proximity Read ↗

MAP kinase and mammalian target of rapamycin are main pathways of gallbladder carcinogenesis: results from bioinformatic analysis of next generation sequencing data from a hospital-based cohort (NCT05404347).Semantic proximity Read ↗

Somatic genetic aberrations in gallbladder cancer: comparison between Chinese and US patientsSemantic proximity Read ↗

Genomic ERBB2 / ERBB3 mutations promote PD-L1-mediated immune escape in gallbladder cancer: a whole-exome sequencing analysisSemantic proximity Read ↗

MAP Kinase and mammalian target of rapamycin are main pathways of gallbladder carcinogenesis: Results from bioinformatic analysis of Next Generation Sequencing data from a hospital-based cohortSemantic proximity Read ↗

The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR.Semantic proximity Read ↗

Genomic profiling of gallbladder carcinoma: Targetable mutations and pathways involved.Semantic proximity Read ↗

Gallbladder cancer in South America: epidemiology and preventionSemantic proximity Read ↗

Comprehensive Molecular Characterization of Gallbladder Carcinoma and Potential Targets for Intervention.Semantic proximity Read ↗

Comprehensive clinicopathological and genomic profiling of gallbladder cancer reveals actionable targets in half of patientsSemantic proximity Read ↗

<i>PIK3CA</i> mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinomaSemantic proximity Read ↗

Identification of MAP kinase pathways as therapeutic targets in gallbladder carcinoma using targeted parallel sequencing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.