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Article

ERBB2 I655V mutation correlates with efficacy of immunotherapy in gallbladder cancer.

World journal of surgical oncology - 4 Feb 2026

Gao Qiang, You Ying-Nan, Lian Shuo, Pan Chang, Zhang Zong-Li, Li Kang-Shuai

Abstract excerpt

BACKGROUND: Gallbladder cancer (GBC) is a highly aggressive malignancy of the digestive system with a poor prognosis. Therefore, the development of effective targeted therapeutic strategies is critical for improving survival outcomes in patients with GBC. Erb-B2 receptor tyrosine kinase 2 (ERBB2) is a proto-oncogene whose overexpression or mutation has been closely linked to the initiation and progression of...

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Source

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Identifiers

PMID: 41634774
DOI: 10.1186/s12957-026-04227-4
PMCID: PMC12964884

Genes

ERBB2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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ERBB2 I655V mutation correlates with efficacy of immunotherapy in gallbladder cancer.PMID 41634774Read ↗

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ERBB2 S310F mutation independently activates PI3K/AKT and MAPK pathways through homodimers to contribute gallbladder carcinoma growth.Semantic proximity Read ↗

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