Article
ERBB2 S310F mutation independently activates PI3K/AKT and MAPK pathways through homodimers to contribute gallbladder carcinoma growth.
Medical oncology (Northwood, London, England) - 28 Apr 2022
Fan Kun, Wang Jiwen, Shen Sheng, Ni Xiaojian, Gong Zijun, Zheng Bohao, Sun Wentao, Suo Tao, Liu Han, Ni Xiaoling, Liu Houbao
Abstract excerpt
Genomic instability and mutability are a prominent character of tumor. The whole-exosome sequence reveals that ERBB2 mutations are the representative mutations of gallbladder carcinoma, which takes potential targets for gallbladder carcinoma therapy. However, the roles of ERBB2 mutations are unclear in gallbladder carcinoma. We identified S310F mutation is the hottest mutation of ERBB2 mutations from TCGA...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.