Article
Overexpression of Dlx2 leads to postnatal condyle degradation.
Molecular medicine reports - 1 Aug 2016
Dai Jiewen, Si Jiawen, Zhu Xiaofang, Zhang Lei, Wu Dandan, Lu Jingting, Ouyang Ningjuan, Wang Xudong, Shen Guofang
Abstract excerpt
Distal-less homeobox 2 (Dlx2), a member of the Dlx family of transcription factors, is important for the development of craniofacial tissues. Previous studies based on knock‑out mutant mice revealed that Dlx2 primarily disturbed the development of tissues from maxillary arch. The present study used a transgenic mouse model to specifically overexpress Dlx2 in neural crest cells in order to investigate the role of...
Topics
- Animals
- Cartilage
- Gene Expression
- Gene Order
- Gene Targeting
- Homeodomain Proteins
- Immunohistochemistry
- Mandibular Condyle
- Mice
- Mice, Transgenic
- Phenotype
- Transcription Factors
- X-Ray Microtomography