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CK2.1, a novel peptide, induces articular cartilage formation in vivo

17 Jun 2016

Abstract excerpt

Bone morphogenetic protein 2 regulates chondrogenesis and cartilage formation. However, it also induces chondrocyte hypertrophy and cartilage matrix degradation. We recently designed three peptides CK2.1, CK2.2, and CK2.3 that activate the BMP signaling pathways by releasing casein kinase II (CK2) from distinct sites at the bone morphogenetic protein receptor type Ia (BMPRIa). Since BMP2 is a major regulator of...

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PMID: 27312334
DOI: 10.1002/jor.23342

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