Article
Therapeutic RNA interference targeting CKIP-1 with a cross-species sequence to stimulate bone formation.
Bone - 1 Feb 2014
Guo Baosheng, Zhang Baoting, Zheng Lizhen, Tang Tao, Liu Jin, Wu Heng, Yang Zhijun, Peng Songlin, He Xiaojuan, Zhang Hongqi, Yue Kevin K M, He Fuchu, Zhang Lingqiang, Qin Ling, Bian Zhaoxiang, Tan Weihong, Liang Zicai, Lu Aiping, Zhang Ge
Abstract excerpt
OBJECTIVES: Casein kinase 2 interacting protein 1 (CKIP-1) is a newly discovered intracellular negative regulator of bone formation without affecting bone resorption. In this study, we aimed to identify a cross-species siRNA sequence targeting CKIP-1 to facilitate developing a novel RNAi-based bone anabolic drug for reversing established osteoporosis. METHODS: Eight specifically designed cross-species CKIP-1...
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