Article
Augmentation of osseous phenotypes in vivo with a synthetic peptide.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Apr 2007
Lin Xinhua, Elliot J J, Carnes D L, Fox W C, Peña L A, Campion S L, Takahashi K, Atkinson B L, Zamora P O
Abstract excerpt
The synthetic peptide B2A2-K-NS augmented the in vitro expression of osseous phenotypes when cells were stimulated with BMP-2, an osteoinductive growth factor. B2A2-K-NS significantly enhanced the effects of BMP-2-induced alkaline phosphatase activity and mineralization. In the absence of BMP-2, B2A2-K-NS did not have an effect on these endpoints. Based on these observations, in vivo studies were conducted to...
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