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Article

Bone morphogenetic protein 1 prodomain specifically binds and regulates signaling by bone morphogenetic proteins 2 and 4.

The Journal of biological chemistry - 23 Mar 2007

Jasuja Reema, Ge Gaoxiang, Voss Nikolas G, Lyman-Gingerich Jamie, Branam Amanda M, Pelegri Francisco J, Greenspan Daniel S

Abstract excerpt

Highly purified fractions of bone extracts capable of inducing ectopic bone formation have been reported to contain peptides corresponding to the mature active regions of the TGF-beta-like bone morphogenetic proteins (BMPs) 2-7, and to the prodomain region of the metalloproteinase BMP1. Co-purification of BMPs 2-7 with BMP1 prodomain sequences through the multiple biochemical steps used in these previous reports...

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Source

Identifiers

PMID: 17255107
DOI: 10.1074/jbc.M610929200

Genes

BMP1
BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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