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Article

HLA-DPB1*04:01 Protects Genetically Susceptible Children from Celiac Disease Autoimmunity in the TEDDY Study.

The American journal of gastroenterology - 1 Jun 2015

Hadley David, Hagopian William, Liu Edwin, She Jin-Xiong, Simell Olli, Akolkar Beena, Ziegler Anette-G, Rewers Marian, Krischer Jeffrey P, Chen Wei-Min, Onengut-Gumuscu Suna, Bugawan Teodorica L, Rich Stephen S, Erlich Henry, Agardh Daniel

Abstract excerpt

OBJECTIVES: Tissue transglutaminase autoantibodies (tTGAs) represent the first evidence of celiac disease (CD) development. Associations of HLA-DR3-DQA1*05:01-DQB1*02:01 (i.e., DR3-DQ2) and, to a lesser extent, DR4-DQA1*03:01-DQB1*03:02 (i.e., DR4-DQ8) with the risk of CD differ by country, consistent with additional genetic heterogeneity that further refines risk. Therefore, we examined human leukocyte antigen...

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Identifiers

PMID: 26010309
DOI: 10.1038/ajg.2015.150
PMCID: PMC4487515

Genes

CDA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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