Article

A protein-centric approach for exome variant aggregation enables sensitive association analysis with clinical outcomes

2019-05-30

Abstract excerpt

Somatic mutations are early drivers of tumorigenesis and tumor progression. However, the mutations typically occur at variable positions across different individuals, resulting in the data being too sparse to test meaningful associations between variants and phenotypes. To overcome this challenge, we devised a novel approach called Gene-to-Protein-to-Disease (GPD) which accumulates variants into new sequence units...

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Literature Corpus work: 33e70882-03ff-5c4c-af69-83b73b58fa11
DOI: 10.1101/653683

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